Vitamin E consists of tocopherols and tocotrienols, in which α-tocotrienol is the most potent neuroprotective form that is also effective in protecting against stroke in rodents.

Cameron Rink, Greg Christoforidis, Savita Khanna, Laura Peterson, Yojan Patel, Suchin Khanna, Amir Abduljalil, Okan Irfanoglu, Raghu Machiraju, Valerie K Bergdall, Chandan K Sen

Publications:
Journal of Cerebral Blood Flow and Metabolism

Date:
Nov 2011

Collaborator:
Hospital Umum Sarawak, Universiti Sains Malaysia

Study:
Trial of Moisturising Cream With/Without Vitamin E (Tocotrienols) and Urea Cream or Urea Cream Alone in Palmar-Plantar Erythrodysesthesia (PPE) Design: Randomized controlled trial (RCT), double blind

Population:
Cancer patients having chemotherapy side effects on skin (hand-foot syndrome or PPE)

Sample size:
90 subjects

Investigational Product:
CC01 moisturizing cream, Urea cream

Collaborator:
EUROFINS EVIC PRODUCT TESTING ROMANIA S.R.L

Population:
Healthy subjects with sensitive skin

Sample size:
50 subjects

Product:
AVRECA Soothing cream, AVRECA Face serum, AVRECA Moisturizing cream

Conclusion:
Supports Hypoallergenic and Suitable for Sensitive skin

The increasing burden of nonalcoholic fatty liver disease (NAFLD) requires innovative management strategies, but an effective pharmacological agent has yet to be found. Apart from weight loss and lifestyle adjustments, one isomer of the vitamin E family is currently recommended for nondiabetic steatohepatitis patients.

Kok-Yong Chin, Sophia Ogechi Ekeuku, Deborah Chia Hsin Chew, Anne Trias

Publications:
Nutrients

Date:
Feb 2023

Vascular dementia (VaD) is a serious global health issue and type 2 diabetes mellitus (T2DM) patients are at higher risk. Palm oil tocotrienol-rich fraction (TRF) exhibits neuroprotective properties; however, its effect on VaD is not reported. Hence, we evaluated TRF effectiveness in T2DM-induced VaD rats.

Sohrab A. Shaikh, Rajavel Varatharajan and Arunachalam Muthuraman

Publications:
International Journal of Molecular Sciences

Date:
Nov 2022

Although pulmonary fibrosis (PF) is considered a rare disease, the incidence thereof has increased steadily in recent years, while a safe and effective cure remains beyond reach. In this study, the potential of tocotrienol-rich fractions (TRF) and carotene to alleviate PF was explored.

Yifei Lu, Yihan Zhang, Dengfeng Xu, Yuanyuan Wang, Da Pan, Pei Wang, Jiayue Xia, Shiyu Yin, Wang Liao, Shaokang Wang and Guiju Sun

Publications:
International Journal of Molecular Sciences

Date:
Nov 2022

The skin is the largest organ of the body that protects from mechanical, thermal, and physical injury. However, the function and appearance of skin visibly degenerates with age due to its frequent exposure to harmful effects of the environment, including ultraviolet irradiation and hazardous substances, in addition to the progression of oxidative stress in aging.

Nur Izyani Ghazali, Rahimah Zahidah Mohd Rais, Suzana Makpol, Kok Yong Chin, Wei Ney Yap, Jo Aan Goon

Publications:
Frontiers in Pharmacology

Date:
Oct 2022

Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is known as a potential therapeutic agent for airway allergic inflammation.

Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung, Wei Ney Yap

Publications:
Allergy, Asthma & Clinical Immunology

Date:
June 2022

Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that are comparable to or exceed those of tocopherols (Toc).

Zaida Zainal, Huzwah Khaza’ai, Ammu Kutty, Radhakrishnan, Sui Kiat Chang

Publications: 
Food Research International

Date:
June 2022

Tocotrienol-rich fraction (TRF) of palm oil has been shown to possess potent antioxidant, anticancer, and cholesterol lowering activities.

Shu-Jing Wu, Po-Len Liu, Lean-Teik Ng

Publications:
Molecular Nutrition and Food Research

Date:
Feb 2022